Rapid correction of hyponatremia is a known risk factor for the development of osmotic demyelination syndrome (ODS), a disorder characterized by the wide spread development of demyelination in the pontine as well as the extra-pontine regions. However, even slow correction of hyponatremia can result in ODS The osmotic demyelination syndrome (ODS) is a central nervous system disorder . that results from neuronal damage related to abrupt fluctuations of osmolality. In spite of the possibility of full or partial recovery in a considerable proportion of cases Thank you Teja, for presenting a case during our Renal Report today - a middle aged woman with post-operative hyponatremia. We discussed the basics of hyponatremia work-up/management, with an interesting discussion on osmotic demyelination syndrome. TOP PEARLS Osmotic demyelination syndrome (ODS) is a very rare, but potentially fatal complication of overly rapid correction of hyponatremia Osmotic demyelination syndrome (ODS) is the term used for both central pontine myelinolysis and extrapontine myelinolysis
Too-rapid correction of sodium can cause osmotic demyelination syndrome (ODS), a form of brain damage Osmotic Demyelination Syndrome Joshua D. King, MD and Mitchell H. Rosner, MD Abstract: The osmotic demyelination syndrome (ODS) has been a recognized complication of the rapid correction of hyponatremia for decades. However, in recent years, a variety of other medical condi-tions have been associated with the development of ODS, independen
The neurologic manifestations associated with overly rapid correction have been called the osmotic demyelination syndrome (ODS; formerly called central pontine myelinolysis or CPM). As will be described below, almost all patients who develop ODS present with a serum sodium concentration of 120 mEq/L or less Objective To describe long-term outcomes of osmotic demyelination syndrome (ODS) in an updated cohort. Methods We performed a retrospective medical records review of cases of ODS at the Massachusetts General and Brigham and Women's Hospitals using International Classification of Diseases-9th edition codes and a text-based search for central pontine myelinolysis , extrapontine myelinolysis, and. Central pontine myelinolysis and extrapontine myelinolysis belong to the spectrum of osmotic demyelination syndromes (ODS), the noninflammatory central nervous system demyelinating conditions frequently associated with chronic alcohol abuse Treatment options for chronic osmotic demyelination syndrome are limited to case reports and only a very few show complete recovery. We report a case of complete recovery of chronic osmotic demyelination syndrome with plasmapheresis. A 43-year-old Sri Lankan man presented with fever, repeated vomiting, unsteady gait, increased tonicity of his right upper limb and paucity of speech for three days
The original description of osmotic demyelination syndrome was by Adams, Victor, and Mancall in 1959 (02). During their studies of the neuropathology of alcoholism, they recognized a peculiar and unique demyelination occurring in the central pons of 4 individuals with alcoholism and malnutrition Objective: To report the incidence rate of osmotic demyelination syndrome (ODS), associated risk factors, treatment, and long-term outcomes in a nationwide cohort. Methods: We conducted a retrospective study of individuals diagnosed with central pontine myelinolysis (ICD-10 code G37.2) in the Swedish National Patient Register during 1997-2011 The term osmotic demyelination syndrome is used to encompass both entities. Throughout the 1970s and 1980s, it became clear that the disease not only occurred in alcoholic or malnourished patients but also was commonly associated with rapid correction of hyponatremia, in which sodium level increases by more than 12 mmol/L/d (, 4)
Complete recovery of chronic Osmotic Demyelination Syndrome with plasma exchange Published: March 08, 2018 6/7 intravenous saline was continued at a rate of 150 ml/hr for next 20 hours. Her Na was corrected to 138meq/lit within 24 hours of her admission. 3 days later she was note She had rapid correction of her serum sodium (Na) from 99meq/l to 138meq/l within 24 hours 1 week prior to development of these symptoms. She was diagnosed as a case of Osmotic demyelination syndrome (ODS) formerly known as central pontine myelinolysis (CPM) which was confirmed by MRI. She underwent Plasma Exchange (PE) on the 20th day since.
developed osmotic demyelination syndrome. Following supportive treatment he made a full recovery. Severe hyponatraemia carries a risk of cerebral oedema with a signiﬁcant mortality, yet correcting it too rapidly can result in osmotic demyelination syndrome, again with potentially disastrous consequences Osmotic demyelination syndrome (ODS) is a life-threatening demyelinating syndrome. The association of ODS with hyperosmolar hyperglycemic state (HHS) has been seldom reported. The aim of this study was to present and discuss previous cases and the pathophysiological mechanisms involved in ODS secondary to HHS. A 47-year-old man arrived to the emergency room due to generalized tonic-clonic. Definition. Osmotic demyelination syndrome (ODS) is brain cell dysfunction. It is caused by the destruction of the layer (myelin sheath) covering nerve cells in the middle of the brainstem (pons).Alternative Names. ODS; Central pontine demyelination Hyponatremia: Osmotic demyelination syndrome Neurological disorders may be seen in end-stage renal disease patients due to uraemia or to complications of dialysis. A dysequilibrium syndrome may be seen, usually soon after or towards the end of haemodialysis. This group of patients has no particular findings on MRI. On the other hand, the osmotic demyelination syndrome has definitive MRI findings, not to date reported with the.
Osmotic demyelination syndrome was formerly known as central pontine myelinolysis. It classically occurs when there is an increase in the serum sodium levels caused by rapid correction of hyponatremia as presented by this case. The typical image characteristic of this lesion on MRI can be round, triangular, bat wing-shaped, or trident. occur with osmotic demyelination syndrome parallels the distribution of oligodendroglial cells (5,6). Alcoholic and malnourished patients generally are deficient in organic osmolytes, a condition that may put them at greater risk for developing osmotic demyelination syndrome (6). Additional comorbid conditions that predispos The osmotic demyelination syndrome (ODS) has been a recognized complication of the rapid correction of hyponatremia for decades. However, in recent years, a variety of other medical conditions have been associated with the development of ODS, independent of changes in serum sodium. This finding suggests that the pathogenesis of ODS may be more complex and involve the inability of brain cells. Osmotic demyelination syndrome is a well-known clinicopathologic entity characterized by edema and demyelination in the pons and extrapontine areas [1-5].Previous studies have noted the MRI findings of osmotic demyelination syndrome in various patient groups [3, 4].The pathogenesis of osmotic demyelination syndrome remains unclear, but many underlying diseases are known to be associated with. Rationale: There is an increasing and compelling need for early recognition of features of osmotic demyelination syndrome (ODS), and a further attempt at correcting this even where presentation is late.. Patient concerns: A 49-year-old male admitted into the emergency department with a complaint of lethargy and severe hyponatremia, with subsequent ODS supervening on initial attempts at correction
. We present a case of 52 year old male presenting with weakness and dysarthria with characteristic MRI appearance  Osmotic demyelination syndrome. Osmotic demyelination syndrome is a rare clinical entity that is characterized by noninflammatory demyelination afflicting the central pons, basal ganglia, thalami, peripheral cortex, and hippocampi 4). Osmotic demyelination syndrome is caused by the destruction of the layer (myelin sheath) covering nerve cells. Osmotic Demyelination Syndrome after Correction of Hyponatremia: A Case Report Vikram Palamalai, Andrew P.J. Olson , Jeffrey P. Hogg, Anthony A. Killeen Medicine - General Internal Medicin
Introduction. The osmotic demyelination syndrome (ODS) is an uncommon disorder, characterised by non-inflammatory demyelination involving the pons and other areas of the central nervous system.1-3 It comprises central pontine myelinolysis (CPM) and extrapontine myelinolysis (EPM). The usual predisposing factors are chronic alcoholism, malnutrition and rapid correction of hyponatraemia.1-3. CPM is one of the two types of osmotic demyelination syndrome (ODS). The other type, known as extrapontine myelinosis (EPM), occurs when myelin is destroyed in areas of the brain that aren't in.
Synopsis. Osmotic demyelination syndrome (ODS), also called central pontine and extrapontine myelinolysis, is a condition caused by destruction of the myelin sheath surrounding nerves in the central nervous system. The damage is thought to be caused by rapid osmolar shifts in the central nervous system, leading to entry of water into brain. Osmotic demyelination syndrome ; Correcting hyponatremia too rapidly may cause two complications: From low to high, your pons will die (osmotic demyelination syndrome); from high to low, your brain will blow (cerebral edema). We list the most important complications. The selection is not exhaustive. Osmotic demyelination syndrome (ODS . With rapid gradient shifts in osmoles associated with both refeeding syndrome and osmotic demyelination disorders, it remains to be seen whether osmotic demyelination syndrome is a central nervous system manifestation of refeeding syndrome [ 25 ] The osmotic demyelination syndrome (ODS) is a serious neurological complication associated with the rapid correction of chronic hyponatremia and is associated with high morbidity and mortality. The incidence of ODS after liver transplantation (LT) is 0.8% to 1.4%, and is higher than in the general population
Osmotic demyelination syndrome is a complex disease entity due to a variety of etiologies, manifesting with symptoms involving diverse systems of the brain. Early identification and removal/correction of conditions leading to osmotic demyelination syndrome are the key to prevent and/or manage this disease Conversely, too rapid correction of hyponatraemia can cause central pontine myelinolysis (also known as osmotic demyelination syndrome). This is caused by large shifts of intracellular water affecting the pons and other parts of the CNS. Symptoms occur 2-4 days later, typically with quadriplegia and pseudobulbar palsy; however, it can take the.
Osmotic demyelination syndrome (ODS) refers to acute demyelination seen in the setting of osmotic changes, typically with the rapid correction of electrolyte disturbance. We present a 29-year-old male patient diagnosed with WD 1 year after the onset of extrapyramidal symptoms Osmotic demyelination syndrome is an acute demyelination process that usually occurs several days following an osmotic stress. This syndrome is rare in adults (0.4% to 0.56%) and even more uncommon in children. We performed a review of all reported pediatric osmotic demyelination syndrome patients from 1960 to 2018. Among all 106 cases, 49 presented with isolated central pontine myelinolysis. Integrative medicine specialist and wellness expert Dr. Sonny Viloria gives information about osmotic demyelination syndrome, and expounds on its causes, eff.. Central pontine myelinolysis is a demyelinating disorder that affects the brainstem white matter, mostly central pons and occasionally cerebral hemispheres (then called 'extrapontine myelinolysis') Usually presents with a subacute progressive quadriparesis with lower cranial nerve involvement. Prognosis is poor
Osmotic brain injury induces demyelination in areas of gray-white apposition and, clinically, results in a delayed neurologic deterioration one to three days following the osmotic challenge. Even with magnetic resonance imaging, review of the literature and this experience suggest that osmotic demyelination cannot reliably be imaged during the. Background: Osmotic demyelination syndrome has been described in patients with rapidly corrected hyponatremia and underlying liver failure is a known risk factor for the above complication. The current case demonstrates that acute pontine demyelination can occur in liver failure patients even in absence of rapid sodium level changes Because this patient developed the osmotic demyelination syndrome (ODS), attention was directed at whether her P Na had risen too far, or too fast. The housestaff had set a maximum target for the rate of rise in her P Na —12 mmol/l/day (0.5 mmol/l/h). 1 Although the patient's P Na was monitored closely, its rise exceeded the target of 0.5. It is important to identify patients at risk from osmotic demyelination syndrome and to correct their hyponatraemia appropriately. Although it is recognised that osmotic demyelination syndrome is a rare disease, its dramatic clinical course points out the importance in different disciplines. Since osmotic demyelination syndrome is an iatrogenic. Osmotic demyelination syndrome (ODS) is an uncommon disorder, characterized by non-inflammatory demyelination involving the pons and other areas of the central nervous system, which may occur for instance as a consequence of an overly rapid correction of hyponatraemia .Here we report a case of ODS occurred after correction of hyponatraemia with isotonic saline solution in a pregnant woman.
Eight (0.5%) patients had incident osmotic demyelination, of whom five (63%) had beer potomania, five (63%) had hypokalemia, and seven (88%) had sodium increase >8 mmol/L over a 24-hour period before magnetic resonance imaging Laboratory tests were normal except for [Na +] of 128 mmol/L. Magnetic resonance imaging of the brain revealed findings consistent with osmotic demyelination syndrome (ODS) 5. The patient's motor function deteriorated to a nearly locked in syndrome; dysarthria progressed to mutism, and emotional lability worsened Concurrent Osmotic Demyelination Syndrome (ODS) and Wernicke's Encephalopathy (WE) in a Patient with Alcoholic Cirrhosis (P4.394) Prateek Thatikunta, Alok Sachdeva, Tanaporn Rasameesoraj, Trisha Dickey, Sushma Chennubhotla, Lisa Rogers. First published April 4, 2016
Osmotic demyelination syndrome occurs when wide fluxes in serum sodium levels are induced by too rapid correction of hyponatremia. Oligodendrocytes, which forms the myelin sheaths, are particularly vulnerable to osmotic changes. If the osmotic stress is severe, myelin sheaths can rupture and split. The pons is the most common site being affected Osmotic demyelination syndrome is a well-known entity caused by rapid correction of sodium imbalance and is reported mainly in malnourished, severely ill, and chronic alcoholic patients. Majority of case reports and studies have shown its relationship with rapid correction of hyponatremia; however, only a few case reports have revealed its. The osmotic demyelination syndrome (ODS), which encompasses central and/or extrapontine myelinolysis, is a rare but serious neurologic complication that can occur after liver transplantation (LT). It can present with myriad neurologic manifestations, from mild dysarthria to quadriparesis and the locked‐in syndrome, and can result in.
Osmotic demyelination syndrome (ODS) is a symmetric, non-inflammatory condition where the myelin fibers are disrupted primarily in the pons. The neuronal cell bodies and axons in the pons are preserved as well as the peripheral fibers and axons of the corticospinal tract (1). This syndrome was previously referred to as central pontine. Osmotic Demyelination Syndrome From Rapid Sodium Correction Causing Evolving Chorea. Full Text. A 41-year-old man was admitted with acute parkinsonism, which deteriorated over the next few days to a state of akinetic mutism (Video 1, segment 1). He obeyed commands to move his eyes but was mute and did not blink, grimace, or move his limbs. Osmotic demyelination syndrome is a rare acute demyelination process with a prevalence of 0.25% to 0.5% in the general population. Its occurrence in infancy is extremely rare. Ranger et al 3 identified 76 pediatric patients with osmotic demyelination syndrome between 1960 and 2009, and of them, only 5 (6.5%) were younger than 1 year